vignettes/rc_exclusivity_nulldist.Rmd
rc_exclusivity_nulldist.RmdThis vignette explains how the null distribution for the Row-Column-Exclusivity test is generated.
A great explanation of the process can be found in the Methods section of “Mutual exclusivity analysis identifies oncogenic network modules” by Ciriello et al. (2012).
It is based off of the algorithm created by Milo et al. in “On the uniform generation of random graphs with prescribed degree sequences” (2003).
In R, the edge swaps can be conducted using igraph::rewire(gr, keeping_degseq(loops = FALSE, niter = N)) where N <- 100 * igraph::ecount(gr).